In X, Wang L, Xu HT, et al. DEC1 is positively

In X, Wang L, Xu HT, et al. DEC1 is positively associated with the malignant phenotype of invasive breast cancers and negatively correlated with the expression of claudin-1. Int J Mol Med. 2013;31:855?0. 53. Lee JC, Sharma M, Lee YH, Lee NH, Kim SY, Yun JS, et al. PAX9 mediated cell survival in oral squamous carcinoma cell enhanced by c-myb. Cell Biochem Funct. 2008;26:892?. 54. Wielscher M, Vierlinger K, Kegler U, Ziesche R, Gsur A, Weinh sel A. Diagnostic performance of plasma DNA methylation profiles in lung cancer, pulmonary fibrosis and COPD. EBio Medicine. 2015;2:927?4. 55. Gorbacheva VY, Kondratov RV, Zhang R, Cherukuri S, Gudkov AV, Takahashi JS, et al. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc Natl Acad Sci U S A. 2005;102:3407?2. 56. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/22763976 Kondratov RV, Kondratova AA, Lee C, GorbachevaVY CMV, Antoch MP. Posttranslational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by cryptochromes. Cell Cycle. 2006;5:890?. 57. Gauger MA, Sancar A. Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer. Cancer Res. 2005;65:6828?4.Submit your next manuscript to BioMed Central and we will help you at every step:?We accept pre-submission inquiries ?Our selector tool helps you to find the most relevant journal ?We provide round the clock customer support ?Convenient online submission ?Thorough peer review ?Inclusion in PubMed and all major indexing services ?Maximum visibility for your research Submit your manuscript at www.biomedcentral.com/submit
Zimin et al. Biology Direct 2014, 9:20 http://www.biologydirect.com/content/9/1/RESEARCHOpen AccessA new rhesus macaque assembly and annotation for next-generation sequencing analysesAleksey V Zimin1, Adam S Cornish2, Mnirnal D Maudhoo2, Robert M Gibbs2, Xiongfei Zhang2, Sanjit Pandey2, Daniel T Meehan2, Kristin Wipfler2, Steven E Bosinger3, Zachary P Johnson3, Gregory K Tharp3, Guillaume Mar is1, Michael Roberts1, Betsy Ferguson4, Howard S Fox5, Todd Treangen6,7, Steven L Salzberg6, James A Yorke1 and Robert B Norgren, Jr2*AbstractBackground: The rhesus macaque (Macaca mulatta) is a key species for advancing biomedical research. Like all draft mammalian genomes, the draft rhesus assembly (rheMac2) has gaps, sequencing errors and misassemblies that have prevented automated annotation pipelines from functioning correctly. Another rhesus macaque assembly, CR_1.0, is also available but is substantially more fragmented than rheMac2 with smaller contigs and scaffolds. Annotations for these two assemblies are limited in completeness and accuracy. High quality assembly and annotation files are required for a wide range of studies including expression, genetic and evolutionary analyses. Results: We report a new de novo assembly of the rhesus macaque genome (MacaM) that incorporates both the original Sanger sequences used to assemble rheMac2 and new Illumina sequences from the same animal. MacaM has a weighted average (N50) contig size of 64 kilobases, more than twice the size of the rheMac2 assembly and almost five times the size of the CR_1.0 assembly. The MacaM chromosome Letrozole assembly incorporates information from previously unutilized mapping data and preliminary annotation of scaffolds. Independent assessment of the assemblies using Ion Torrent PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/9547713 read alignments indicates that MacaM is more complete and accurate than rheMac2 and CR_1.0. We assembled messenger RNA sequences from se.