18.2 Main Histocompatibility Complexes And Antigen-Presenting Cells - …

Macrophages and dendritic cells use related mechanisms for processing and presentation of antigens and their epitopes in affiliation with MHC II; B cells use considerably totally different mechanisms that might be described further in B Lymphocytes and Humoral Immunity. For now, we'll concentrate on the steps of the process as they pertain to dendritic cells. After a dendritic cell recognizes and attaches to a pathogen cell, the pathogen is internalized by phagocytosis and is initially contained within a phagosome. Lysosomes containing antimicrobial enzymes and chemicals fuse with the phagosome to create a phagolysosome, the place degradation of the pathogen for antigen processing begins. APCs don't current all potential epitopes to T cells; only a collection of essentially the most antigenic or immunodominant epitopes are offered.

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